Coagulation and Bleeding Disorders
Bleeding is one of the most primal responses of the human body to injury. In most cases, it stops on its own within minutes, thanks to a tightly controlled biological process called haemostasis. But when haemostasis fails — whether because a vessel bleeds too much, too long, or clots too easily — the consequences can range from uncomfortable bruising to life-threatening haemorrhage. The medical laboratory is at the heart of diagnosing and monitoring bleeding and clotting disorders. Through a carefully selected panel of tests, clinical scientists can pinpoint exactly where the haemostatic system has broken down and guide clinicians toward the right treatment. In this post, we take a deep dive into the science of coagulation, the most common disorders associated with it, and the laboratory tests that help us understand them. 1. Haemostasis: The Body's Clotting System Haemostasis is the process by which bleeding stops after injury. It involves three overlapping phases that work toge...